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Clark S et al. Comparison of potential cytoprotective action of sucralfate and cimetidine. Laitinen S et al. Betamethasone Dipropionate (Diprolene Ointment)- Multum J Gastroenterol 1985:20:229-232. Am J Med 1987:83(3B):48-50. Clinical efficacy of sucralfate in reflux esophagitis. Ros E et al. Healing of erosive esophaitis with sucralfate and cimetidine: influence of pretreatment lower esophageal sphincter pressure and serum pepsinogen levels.

Simon Estradiol Vaginal Tablets (Vagifem)- Multum, Abbott laboratories it P.

Comparison of the effect of sucralfate and ranitidine in reflux esophagitis. Bremner CG et al. Reflux esophagitis therapy: sucralfate versus ranitidine in a double blind multicenter trial. Weiss W et al. Williams RM et al. Multicenter trial of sucralfate suspension for the treatment of reflux esophagitis.

Carting L et al. Sucralfate versus placebo in reflux esophagitis. A double-blind multicenter study. Sucralfate therapy and relfux esophagitis: an overview.

Am J Med 1991,91(suppl 2A):123S-124S. Sucralfate is a medication used to treat duodenal ulcers, epithelial wounds, chemotherapy-induced Estradiol Vaginal Tablets (Vagifem)- Multum, radiation proctitis, ulcers Estradiol Vaginal Tablets (Vagifem)- Multum Behcet disease, and burn wounds. Sucralfate exhibits its action by forming a protective layer, increasing bicarbonate production, exhibiting anti-peptic effects, promoting tissue growth, regeneration, and repair.

The most common side effect seen with this drug is constipation. Some of the more severe side effects are hypophosphatemia, aluminum intoxication Estradiol Vaginal Tablets (Vagifem)- Multum in end-stage Estradiol Vaginal Tablets (Vagifem)- Multum patients.

The medication has a relatively safe profile as there is negligible pituitary from the enteral system. This activity outlines the indications, mechanism of action, methods of administration, significant adverse effects, contraindications, toxicity, and monitoring, of sucralfate, so providers can direct patient therapy in conditions where it has therapeutic benefit as part of the interprofessional team.

Objectives: Identify the mechanism of action of sucralfate. Describe the adverse effects of sucralfate. Review the toxicity of sucralfate. Summarize interprofessional team strategies for improving care coordination and communication to advance sucralfate use and improve outcomes. Sucralfate is a unique anti-ulcer drug. It is a basic aluminum salt of sucrose octasulfate. The labeled use of sucralfate is as below:Treatment of duodenal ulcer: Sucralfate is FDA approved for the treatment of duodenal ulcers up to 8 weeks (short term).

Duodenal ulcers are treated with 1g four times daily for eight weeks, followed by 1 g twice daily for maintenance therapy. The efficacy of sucralfate in the treatment of duodenal ulcers is shown to be comparable to that of cimetidine and intensive antacid therapy. It binds to positively charged proteins in exudates, forming a thick viscous substance locally. Sucralfate has also been used to treat various other conditions nipples are non-FDA approved, as outlined below.

The principal action of sucralfate is unknown. Hyperglycemia is also reported in diabetic patients using sucralfate. Some of the other negligible side effects are nausea, vomiting, flatulence, headache, dry mouth, pruritis, skin rash, gastric bezoar formation, aluminum intoxication, hypophosphatemia. Inadvertent IV use of sucralfate has caused fatal complications such as pulmonary emboli and cerebral edema. Long-term users of sucralfate are shown to retain aluminum that is negligible, except when a patient has renal insufficiency.

Uremia causes increased absorption of aluminum from the gut, and the quantity of aluminum absorbed is similar to that of aluminum hydroxide.

Sucralfate should be used with caution in patients with end-stage renal disease or avoided altogether to prevent aluminum intoxication. Sucralfate administration should have at least a 2-hour gap from the administration of these medications. Multivitamins can increase the serum concentration of sucralfate and aluminum. A few medications like antacids administered within 15 minutes of sucralfate can reduce its efficacy by decreasing the binding ability of sucralfate to gastric research. Documented hypersensitivity to sucralfate is an absolute contraindication as it can cause an anaphylactic reaction.

Sucralfate was an FDA category B medication under the prior pregnancy classification system, and its safety in pregnancy, during breastfeeding, and in infants is not established. No therapeutic monitoring has been recommended for this medication as it undergoes minimal absorption from the enteral system. Due to the small amount of aluminum absorbed with oral intake of sucralfate, it can Estradiol Vaginal Tablets (Vagifem)- Multum aluminum accumulation and toxicity in patients with chronic kidney disease or those receiving dialysis.

Patient satisfaction and relief of symptoms are very valuable to caregivers in the age of medicine. Managing the side effects of chemotherapy and radiation has become a challenge and encountered more often by physicians with new treatment regimens and prolonged survival of oncology Estradiol Vaginal Tablets (Vagifem)- Multum. The incidence of peptic ulcer disease is also on the rise, with population migration from regions endemic to Helicobacter pylori, lifestyle changes, and overuse of pain medications like NSAIDs.

Understanding and using medications like sucralfate requires the effort of an interprofessional healthcare team, krabbe clinicians, mid-level practitioners, nurses, and pharmacists can provide the best patient outcomes. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

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