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Sepiapterin reductase (SPR) catalyzes the reduction of sepiapterin to dihydrobiopterin (BH2), the precursor for tetrahydrobiopterin (BH4), a cofactor critical for nitric oxide biosynthesis and alkylglycerol and aromatic amino acid metabolism. SPR also mediates chemical redox cycling, catalyzing one-electron reduction of redox-active chemicals, including quinones and bipyridinium herbicides (e.

Using recombinant human SPR, sulfonamide- and sulfonylurea-based sulfa drugs were found to be potent noncompetitive inhibitors of both sepiapterin reduction uptodate com redox cycling. The ability of the sulfa drugs to inhibit redox cycling may ameliorate ROS-mediated toxicity generated by redox active drugs and chemicals, uptodate com to their anti-inflammatory activity. NOTE: We request your email address only to inform the uptodate com that it was you who recommended this article, and that it is not junk mail.

We do not retain these email addresses. Skip to main content Advertisement googletag. Uptodate com and Jeffrey D. FootnotesReceived November 21, 2014. Accepted December 29, 2014. JPET articles become freely available 12 months after publication, and remain freely available for 5 years. Non-open access uptodate com that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the uptodate com purchase feature at the bottom of the page.

Click here for information on institutional subscriptions. Torticollis uptodate com for information on individual ASPET membership. Purchase accessYou may purchase access to this article. This will require you to create uptodate com account if you don't already have one. PreviousNext Back to top In this issue Journal of Pharmacology and Experimental Therapeutics Vol.

Citation Tools Uptodate com ArticleToxicology Shaojun Yang, Yi-Hua Jan, Vladimir Mishin, Jason R. Sulfamethoxazole (pictured) is a sulfa drug, namely a synthetic antibiotic that contains a sulfonamide group. At high doses, this compound is used to treat Pneumocystis pneumonia, a uptodate com fungal infection.

At elevated dosage, however, sulfamethoxazole elicits neurological side effects such as headache, insomnia, nervousness, and fine tremors. The researchers reveled that, at high does, sulfamethoxazole and other sulfa drugs inhibit the synthesis of tetrahydrobiopterin, the essential uptodate com of the enzyme that converts L-tyrosine into L-DOPA (tyrosine hydroxylase).

As a consequence, they ultimately lower L-DOPA levels. Based on these findings, L-DOPA might be used as supplement to prevent sulfamethoxazole- induced side effects. Please note uptodate com to comment on an article you must be registered and logged in. Registration is for free, you may already be registered to receive, e. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation. If you would uptodate com to reuse any content, in print or online, from ChemistryViews.

Society: Chemistry Europe News: Who's Next. Nobel Prize in Chemistry 202. Drugsrelated chemically to sulfanilamide.

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